Equivalent Replacement Engine

Every reaction
has a greener
equivalent.

Paste any lab protocol. Scored against all 12 Principles of Green Chemistry. Specific, chemically-validated swaps — in seconds.

ANALYZE A PROTOCOL
12
Green Chemistry Principles
<0.01¢
Per analysis run
Process

How It Works

Paste Your Protocol

Drop in any lab protocol — synthesis steps, reagents, solvents, conditions. Plain text, PDF-extracted, or directly from ELN.

Scored Against 12 Principles

Each step is evaluated across all 12 Green Chemistry principles. Hazard data from PubChem. Solvent data from CHEM21. Atom economy from structure.

Accept or Reject Swaps

Specific, chemically-validated substitution proposals — not generic advice. One click to accept; your modified protocol is ready to export.

Framework

The 12 Principles
of Green Chemistry

Score your protocol →
P1
Prevention
Waste prevention over treatment
P2
Atom Economy
Maximize atom incorporation
P3
Less Hazardous
Design safer syntheses
P4
Safer Chemicals
Reduce toxicity by design
P5
Safer Solvents
Avoid auxiliary substances
P6
Energy Efficiency
Minimize energy input
P7
Renewable Feedstocks
Use renewable raw materials
P8
Reduce Derivatives
Avoid unnecessary steps
P9
Catalysis
Use catalytic reagents
P10
Design for Degradation
Products should break down
P11
Real-time Analysis
Monitor, prevent pollution
P12
Accident Prevention
Inherently safer chemistry
The Product

From protocol
to greener lab
in minutes.

Triazolo-peptidomimetic synthesis — 38 recommendations, 12 principles scored, full revised protocol. Actual output.

AUTO
app.greenchemistry.ai/analyze/triazolo-peptidomimetics

Recommendations (38)

1 accepted
Step 1HIGHhigh confidence
#1 Prevention#3 Less Hazardous#5 Safer Solvents#12 Accident Prevention
ORIGINAL
DMF

Classified carcinogen (CMR1B). Used as primary solvent across all 9 synthesis steps.

RECOMMENDED
DMSO

Comparable performance in SPPS. Non-carcinogenic. Eliminates CMR1B exposure across all steps.

Yield: Comparable; DMSO's higher bp may aid microwave steps

Source: CHEM21 solvent guide, PubChem

Step 2MEDIUMhigh confidence
#1 Prevention#6 Energy Efficiency
ORIGINAL
5 equiv AA + DIC + HOBt

5 equivalents excess generates significant chemical waste without proportional yield benefit.

RECOMMENDED
3 equiv with optimized conditions

Comparable coupling efficiency (>98%) with 40% less amino acid waste per cycle.

Yield: Comparable with optimized coupling time

Step 12HIGHhigh confidence
#3 Less Hazardous#12 Accident Prevention
ORIGINAL
95% TFA cleavage cocktail

Trifluoroacetic acid is highly corrosive and generates fluorinated waste with long environmental persistence.

RECOMMENDED
Hydrochloric acid alternative

HCl-based cleavage eliminates persistent fluorinated byproducts. Comparable deprotection for standard amino acids.

Yield: Verify efficiency for Pbf-protected Arg residues

+ 35 more recommendations across steps 1–14

The Stack

DKit and PubChem power every recommendation. GreenChemistry.ai is AI as interface — making decades of deterministic cheminformatics accessible in a conversation.

Chemistry is solved math. The scoring algorithms are deterministic, auditable, and citable — AI handles the interface, not the science. The same engine that runs a single research protocol scales to production-grade deployment across an entire R&D org.

Actually Green AI
<0.1%
the energy cost
of a SOTA model
Typical LLM inference: ~10,000W.
Ours: one local, high-memory,
low-power machine.
Cheminformatics
RDKit
Industry-standard. Auditable. Reproducible.
Chemistry Database
PubChem
NCBI's public compound database. Citable.
Deployment Path
Research → Production
Same engine, lab bench to org-wide.
Enterprise Access

Talk to us
before your
next synthesis.

Custom integrations, ELN connectors, DOZN export, and team dashboards for R&D teams and sustainability officers.

ANALYZE A PROTOCOL — FREEREQUEST ENTERPRISE DEMO

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